Stephanopoulos, Stefanopoulos (), feminine: Stephanopoulou, Stefanopoulou () is a Greek surname. Notable people with the surname include:
Andreas Stephanopoulos (1860–1938), Greek politician Anna Stefanopoulou, Greek-American mechanical engineer Christos Stephanopoulos (1853–1918), Greek politician Konstantinos Stephanopoulos (1926–2016), Greek politician, President of Greece Fotini Dekazou Stefanopoulou, academic and politician George Stephanopoulos (born 1961), Greek-American journalist and political adviser Georgios Stephanopoulos (born 1962) Greek boxer Gregory Stephanopoulos, American chemical engineer and professor Maria Flytzani-Stephanopoulos (1950–2019) American chemical engineer Stefanos Stephanopoulos (1898–1982), Greek politician, Prime Minister of Greece