"Mr. Big Stuff" is a 1971 single by Jean Knight.

Mr. Big Stuff may also refer to:

Mr. Big Stuff (album), a 1971 album by Jean Knight "Mr. Big Stuff", a song by Heavy D & the Boyz from the 1987 album Living Large "Mr. Big Stuff", a single by Grandmaster Mele-Mel & Scorpio from the 1997 album Right Now "Mr. Big Stuff", a song by Biz Markie first released on the album On the Turntable (1998)