25B-NBOH

25B-NBOH, also known as N-(2-hydroxybenzyl)-4-bromo-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine, 2C, and N-benzylphenethylamine families related to 2C-B and 25B-NBOMe. It has been sold and encountered as a novel designer drug.

Interactions

Pharmacology Pharmacodynamics 25B-NBOH acts as a potent serotonin receptor agonist with similar affinity to the better-known compound 25B-NBOMe at 5-HT2A and 5-HT2C receptors with affinities (Ki) of 5.0nM and 0.40nM, respectively. It fully substitutes for DOM in rodent drug discrimination tests, but with about 26-fold greater potency in comparison. The drug was also 18-fold more potent in substituting for DOM than 25B-NBOMe in rodents. In addition to its psychedelic-like effects, 25B-NBOH produces hypolocomotion in rodents, but with about 60% of the potency of DOM and about the same potency as 25B-NBOMe. There was an 853-fold difference in its potency in the drug discrimination and hypolocomotion tests, which is described as unusual among psychedelics and warranting further investigation.

Chemistry Synthesis The chemical synthesis of 25B-NBOH has been described.

Analogues Analogues of 25B-NBOH include 25B-NBOMe, 25I-NBOH, 25C-NBOH, and 2C-B, among others.

History 25B-NBOH was first described in the scientific literature by Ralm Heim and colleagues by 2000. It was first encountered and described as a novel designer drug by 2016.

Society and culture Legal status Canada 25B-NBOH is a controlled substance in Canada under phenethylamine blanket-ban language.

Sweden The Riksdag added 25B-NBOH to Narcotic Drugs Punishments Act under Swedish Schedule I ("substances, plant materials and fungi which normally do not have medical use") as of January 26, 2016, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:35 listed as 25B-NBOH, and 2-([2-(4-bromo-2,5-dimetoxifenyl)etylamino]metyl)fenol.

United Kingdom

United States 25B-NBOH is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

25B-NBOH

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