The Moore-Jacobs House is a historic house at 500 North Main Street in Clarendon, Arkansas. It is a single-story wood-frame structure, with a side-gable roof and an projecting entry pavilion with a pedimented gable supported by paired square columns. Built in about 1870, this Greek Revival house is a testament to that style's enduring popularity in Arkansas. It was moved across the street from its original location in 1931. It was also for many years home to Margaret Moore-Jacobs, known for her inspirational writings.

The house was listed on the National Register of Historic Places in 1983.

See also National Register of Historic Places listings in Monroe County, Arkansas

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