Cuff is a surname. Notable people with the surname include:
Athletes Anthony Cuff (born 1957), New Zealand cyclist Ed Cuff Jr. (born 1961), American golfer John Cuff (baseball) (1864–1916), American baseball player Katherine Cuff, Canadian professor of economics Leonard Cuff (1866–1954), New Zealand cricketer and all-round sportsman, and sports administrator Omar Cuff (born 1984), American football running back Pat Cuff (born 1952), English footballer Ward Cuff (1914–2002), American football player Wayne Cuff (born 1971), Jamaican cricketer Will Cuff (1868–1949), chairman of Everton Football Club, England
Others Agnes Cuff (1890–?), mother of actor Alec Guinness Dana Cuff, American architect theorist and professor John Cuff (optician) (1708–1772), English scientific instrument maker John Cuff (politician) (1805–1864), New Zealand politician
See also Cuffe, with a list of people surnamed 'Cuffe'