Duquesnoy is a surname derived from the Picard commune of Le Quesnoy, and may refer to:
Adrien Duquesnoy (1759–1808), French political figure during the French Revolution Ernest Dominique François Joseph Duquesnoy (1749–1795), Radical French political figure during the French Revolution and brother of Florent Joseph Duquesnoy Florent Joseph Duquesnoy (1761–1801), French general during the French Revolution and brother of Ernest Dominique François Joseph Duquesnoy François Duquesnoy (1597–1643), Flemish sculptor and son of Jérôme the Elder (c. 1570–c. 1641), Flemish sculptor of the Manneken Pis Jérôme Duquesnoy the Younger (1602–1654), Flemish architect and sculptor, son of Jérôme the Elder Tom Duquesnoy (born 1993), French mixed martial artist