Kernaghan is a surname. Other spellings include Kernochan, Kernohan, Kernighan, and Kernahan. Notable people with the surname include:

Business James Powell Kernochan (1831–1897), American businessman Catherine Lorillard Kernochan (1835–1917), his wife

Entertainment Roxanne Kernohan (1960–1993), Canadian actress Paolo Kernahan, Trinidadian television presenter Sarah Kernochan (born 1947), American filmmaker

Law J. Frederic Kernochan (1842–1929), American attorney Mary Stuart Whitney Kernochan (1849–1922), his wife John Marshall Kernochan (1919–2007), American law professor

Literature Coulson Kernahan (1858–1943), English novelist Eileen Kernaghan (born 1939), Canadian novelist Robert Kirkland Kernighan (1854–1926), Canadian poet

Music Lee Kernaghan (born 1964), Australian country music singer and songwriter Ray Kernaghan, Australian country music artist Tania Kernaghan (born 1968), Australian country music singer

Politics Charles Kernaghan (1948–2022), American activist Liz Kernohan (1939–2004), Australian politician Mae Kernaghan (1901–1980), former Republican member of the Pennsylvania House of Representatives Patricia Kernighan, American politician Terence Kernaghan Canadian politician

Science James Watson Kernohan, American pathologist Brian Kernighan (born 1942), Canadian computer scientist

Sport Alan Kernaghan (born 1967), professional football player and coach David Kernahan (born 1965), Australian rules football player Hugh Kernohan (born 1958), Scottish fencer Mike Kernaghan (born 1955), lawn bowls competitor for New Zealand Stephen Kernahan (born 1963), Australian rules football player

See also Margaret Kernochan Leech (1893–1974), American historian and fiction writer William Kernahan Thomas (1911–2001), American judge Kernohan, Edmonton, neighbourhood in Edmonton, Canada Kernahan, St. Catharines, neighbourhood in St. Catharines, Canada Kernohan's notch, a medical sign