Central Hotel may refer to:
Australia Central Hotel, Cairns, Queensland, Australia, a heritage-listed building Central Hotel, Stanthorpe, Queensland, Australia, a heritage-listed building
Germany Central-Hotel, former hotel in Berlin at Friedrichstraße
Ireland Central Hotel fire, Bundoran, Co Donegal, Ireland
United Kingdom Central Hotel (Glasgow), Scotland Central Hotel, Douglas, Isle of Man, one of Isle of Man's Registered Buildings
United States Central Hotel (Mount Joy, Pennsylvania), listed on the National Register of Historic Places