Sätra Nature Reserve () is a nature reserve in northern Uppsala County in Sweden.
Sätra Nature Reserve consists of an area of old-growth forest dominated by spruce. The forest has been untouched since at least the 1860s. A number of orchids are known to grow in the area, including Cypripedium calceolus and broad-leaved helleborine. The nature reserve is part of the EU-wide Natura 2000-network.
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