Peter Kranke (born 10 July 1973, Würzburg) is anesthetist and professor of anesthesiology at the University of Würzburg, Germany. Kranke is known for the design and conduct of clinical studies and for performing systematic reviews in the context of perioperative medicine. He published numerous papers on research focussed on evidence-based medicine and interventional and observational trials on postoperative nausea and vomiting and other issues in conjunction with perioperative medicine and associated topics including patient blood management. The area of his clinical responsibility and interest, among others, is the safe provision of anesthesia and analgesia in obstetrics and gynecology.
Biography Kranke studied medicine at the University of Würzburg from 1994 to 99, followed by a practical year (PJ) at the University of Heidelberg and at the Cantonal Hospital of Baden Switzerland. In 2000 he was promoted to doctor of medicine ("magna cum laude"). In 2005 he was approved as medical specialist in anesthesiology (consultant anesthetist) and was habilitated in the same year with a work on the application of evidence-based medicine in the perioperative period with special focus on postoperative nausea and vomiting (PONV).Habilitation thesis in the catalogue of the German National Library He also holds an MBA since 2005. In 2007 he was named senior physician at the Department of Anaesthesia and Critical Care at the University of Würzburg. There he heads the clinical research since 2008. In 2009 he was named full professor of anesthesiology at the University of Würzburg. Kranke also holds special titles for intensive care medicine, pain management palliative care, emergency medicine, acupuncture and medical quality management (Bavarian chamber of physicians) as well as qualifications with respect to the conduct of clinical trials (phase II to IV). The working group "clinical studies" and trial management, headed by Kranke,Department of Anaesthesia and Critical Care, University Hospitals of Würzburg compiles systematic reviews on interventions in health care with associated economic benefit assessment according to the criteria of the cochrane collaboration, other systematic reviews and has a coordinating role with respect to clinical trials.
Scientific contribution The main area of expertise and emphasis of Kranke's scientific work was in the area of observational and interventional trials on risk factors for PONVC. C. Apfel, P. Kranke, L. H. J. Eberhart. Comparison of surgical site and patient's history with a simplified score for the prediction of postoperative nausea and vomiting. Anaesthesia 2004; 59: 1078–1082 as well as investigator initiated trials and industry-driven trials to investigate interventions aiming at the prevention or treatment of PONV.An International Multicenter Protocol to Assess the single and combined benefits of antiemetic interventions in a Controlled clinical Trial of a 2 ' 2 ' 2 ' 2 ' 2 ' 2 factorial design (IMPACT). Controlled Clinical Trials 2003; 24:736–51C. C Apfel, P. Kranke, M. H. Katz, C. Goepfert, T. Papenfuss, S. Rauch, R. Heineck, C.-A. Greim, N. Roewer. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. British Journal of Anaesthesia 2002; 88: 659–668Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, Zernak C, Danner K, Jokela R, Pocock SJ, Trenkler S, Kredel M, Biedler A, Sessler DI, Roewer N: A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. NEJM. 2004 Jun 10;350(24):2441-51. Among these trials, many studies were aiming to get a label for the indication of PONV prevention (phase II and III trials).Kranke P, Röhm KD, Diemunsch P, Gan TJ, Apfel CC, Eberhart L, Minkowitz HS, Wallenborn J, Chassard D, Lebuffe G, Fox GM, Tramèr MR: Intravenous buspirone for the prevention of postoperative nausea and vomiting. Eur J Clin Pharmacol. 2012 Nov;68(11):1465–72. doi: 10.1007/s00228-012-1284-8. Epub 2012 May 1.Kranke P, Eberhart L, Motsch J, Chassard D, Wallenborn J, Diemunsch P, Liu N, Keh D, Bouaziz H, Bergis M, Fox G, Gan TJ: I.V. APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial. Br J Anaesth. 2013 Dec;111(6):938-45. doi: 10.1093/bja/aet251. Epub 2013 Jul 19.P. Kranke, J. P. Thompson, P. L. Dalby, L. H. Eberhart, E. Novikova, B. M. Johnson, S. F. Russ, R. Noble, R. A. Brigandi. Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron. British Journal of Anaesthesia 2015; Mar;114(3):423–9 Further, Kranke´s group conducted numerous systematic reviews on interventions in conjunction with the perioperative period,P. Kranke, L. H. Eberhart, N. Roewer, M. R. Tramèr. Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering – A quantitative systematic review of randomized controlled trials. Anesthesia and Analgesia 2004; 99: 718–727 among other, various antiemetics.P. Kranke, A. M. Morin, N. Roewer, H. Wulf, L. H. Eberhart. The efficacy and safety of transdermal scopolamine for the prevention of postoperative nausea and vomiting: A quantitative systematic review. Anesthesia and Analgesia 2002; 95: 133–143A. Schnabel, L. Eberhart, A. Morin, H. van Aken, N. Roewer, P. Kranke. Efficacy and safety of perphenazine in the prevention of postoperative nausea and vomiting (PONV): A quantitative systematic review. Anesthesia & Analgesia 2008; 106: S-3P. Kranke, A. M. Morin, N. Roewer, L. H. Eberhart. Dimenhydrinate for prophylaxis of postoperative nausea and vomiting. A meta-analysis of randomized controlled trials. Acta Anaesthesiologica Scandinavica 2002; 46: 238–244 In addition, Kranke has set up and validated many tools and prognostic instruments with respect to the prediction of PONV and other adverse events in the perioperative phase, such as PONVP. Kranke, L. H. Eberhart, H. Toker, N. Roewer, H. Wulf, P. Kiefer. A prospective evaluation of the POVOC-score for the prediction of postoperative vomiting in children. Anesthesia and Analgesia 2007; 105: 1592–1597L. H. J. Eberhart, G. Geldner, P. Kranke, A. M. Morin, A. Schäuffelen, H. Treiber, H. Wulf. Development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients. Anesthesia and Analgesia 2004; 99: 1630–1637 and shivering.Eberhart LH, Döderlein F, Eisenhardt G, Kranke P, Sessler DI, Torossian A, Wulf H, Morin AM: Independent risk factors for postoperative shivering. Anesth Analg. 2005 Dec;101(6):1849–57. An additional emphasis was put on the pharmacoeconomic assessment and analysisL. Eberhart, T. Koch, P. Kranke, D. Rüsch, A. Torossian, S. Nardi-Hiebl. Activity-based cost analysis of opioid-related nausea and vomiting among inpatients.J Opioid Manag. 2014 Nov–Dec;10(6):415–22 and implementation studies and analyses on the impact of algorithms with regard to the quality of care.P. Kranke, L. H. Eberhart, T. J. Gan, N. Roewer, M. R. Tramèr. Algorithms for the prevention of postoperative nausea and vomiting: An efficacy and efficiency simulation. European Journal of Anaesthesiology 2007; 24: 856–867 The focus on evidence-base medicine in anaesthesia soon led to the conduct of Cochrane Reviews and their regular update in the field of perioperative medicine and associated topics, a topic that still constitutes a main focus of the group.P. Kranke, M. Bennett, I. Roeckl-Wiedmann, S. Debus. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev. 2004;(2)P. Kranke, M.H. Bennett, James M. Martyn-St, A. Schnabel, S.E. Debus. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev. 2012 Apr 18;4M.H. Bennett, S. Weibel, J. Wasiak, A. Schnabel, C. French, P. Kranke. Hyperbaric oxygen therapy for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Nov 12 This expertise and focus has led to the participation in many consensus and guideline development groups.I. Smith, P. Kranke, I. Murat, A. Smith, G. O'Sullivan, E. Søreide, C. Spies, B. in't Veld; European Society of Anaesthesiology. Eur J Anaesthesiol. 2011 Aug;28(8):556–69Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, Watcha M, Chung F, Angus S, Apfel CC, Bergese SD, Candiotti KA, Chan MT, Davis PJ, Hooper VD, Lagoo-Deenadayalan S, Myles P, Nezat G, Philip BK, Tramèr MR: Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014 Jan;118(1):85–113. doi: 10.1213/ANE.0000000000000002. Apart from perioperative medicine in general, another area of research is in the field of obstetric anaesthesia and analgesia, quality of recovery and patient safety. Among others, Kranke's interest was in evaluating alternative methods for the provision of labour analgesia and its safe implementation in clinical practice.A. Schnabel, N. Hahn, R. Muellenbach, T. Frambach, A. Hoenig, N. Roewer, P. Kranke. Obstetric analgesia in German clinics. Remifentanil as alternative to regional analgesia. Der Anaesthesist. 2011 Nov; 60(11):995–1001A. Schnabel, N. Hahn, J. Broscheit, R.M. Muellenbach, L. Rieger, N. Roewer, P. Kranke. Remifentanil for labour analgesia: a meta-analysis of randomised controlled trials. Eur J Anaesthesiol. 2012 Apr;29(4):177–85.P. Kranke, P. Lavand'homme. The relief of pain in labour and the role of remifentanil. Eur J Anaesthesiol. 2012 Mar; 29(3):116–20. Very early, and based on results of conducted systematic reviews, Kranke and colleagues highlighted the suspicious trial results published by Fujii and colleagues.P. Kranke, C.C. Apfel, N. Roewer, Y. Fujii. Reported data on granisetron and postoperative nausea and vomiting by Fujii et al. Are incredibly nice! Anesth Analg. 2000 Apr;90(4):1004-7.P. Kranke, C.C. Apfel, L.H. Eberhart, M. Georgieff, N. Roewer. The influence of a dominating centre on a quantitative systematic review of granisetron for preventing postoperative nausea and vomiting. Acta Anaesthesiol. Scand. 2001 Jul;45(6):659–70.C.C. Apfel, P. Kranke, C.A. Greim, N. Roewer. Non-systematic serial publishing is not appropriate and ethically questionable. Acta Anaesthesiol. Scand. 1999 Apr;43(4):486–7P. Kranke, C.C. Apfel, C.A. Greim, N. Roewer. Methodological problems arising from 'serial publishing' on the effectiveness of granisetron in PONV. Br J Anaesth. 1999 Mar;82(3):481–3. Findings, that were negated for a long time, but finally reconfirmed by subsequent, comprehensive analyses.P. Kranke. Putting the record straight: granisetron's efficacy as an antiemetic 'post-Fujii'. Anaesthesia. 2012 Oct;67(10):1063-7. doi: 10.1111/j.1365-2044.2012.07318.x. Epub 2012 Aug 16.J.B. Carlisle. The analysis of 168 randomised controlled trials to test data integrity. Anaesthesia. 2012 May;67(5):521–37.
Awards Admitted a Fellow of the European Society of Anaesthesiology and Intensive Care, FESAIC August-Bier-Preis of the DGAI (2018) Carl-Ludwig-Schleich Price of the DGAI (2016) ESA-Meta-Analysis Grant (2013) 1st Lilly Quality-of-Life Price (2004)
Memberships