Chromosome 9 open reading frame 152 is a protein that in humans is encoded by the C9orf152 gene. The exact function of the protein is not completely understood.
Gene The human gene C9orf152 is located on the long (q) arm of Chromosome 9. Its cytogenetic location is 9q31.1. It has one known alias: bA470J20.2. The DNA sequence encoding C9orf152 contains a single intron. The final mRNA consists of 2698 base pairs. Nucleotides 66-68 encode an upstream in frame stop codon.
Evolution C9orf152 has orthologs in mammals, birds, reptiles and amphibians. No orthologs have been detected in bony fish or in any invertebrates. The following table lists a subset of conserved orthologs. Scientific name Common name Accession number Sequence length (aa) Percent identity Percent similarity Homo sapiens Human NP_001013011.2 239 - - Pan troglodytes Chimpanzee XP_001145187 239 98 98 Tarsius syrichta Philippine tarsier XP_008064367 237 78 85 Ceratotherium simum simum Rhinoceros XP_004423784 239 78 82 Sus scrofa Wild boar XP_003122117 239 74 83 Equus caballus Horse XP_001491697 239 74 80 Tursiops truncatus Bottlenose dolphin XP_004329084 234 73 81 Heterocephalus glaber Naked mole rat XP_004903816 239 74 84 Orcinus orca Killer whale XP_004269444 231 72 79 Mus musculus Mouse NP_848842 236 62 72 Rattus norvegicus Rat XP_003754080 234 62 70 Chelonia mydas Green sea turtle XP_007059491 267 33 49 Nestor notabilis Kea XP_010009525 265 34 49 Python bivittatus Burmese python XP_007428415 234 30 44 Meleagris gallopavo Wild turkey XP_010710660 267 29 43 Pelodiscus sinensis Chinese softshell turtle XP_006120615 268 29 43 Haliaeetus albicilla White tailed eagle XP_009911401 266 33 48 Xenopus tropicalis Western clawed frog XP_004915565 226 31 45
Differences among shown orthologs suggest a slow rate of evolution.
Protein Chromosome 9 open reading frame 152 contains 239 amino acids. The molecular weight is 26.3 kilodaltons. The protein has a high chance of existing nuclear region of cells. There are likely no transmembrane regions. One isoform exists, containing 194 amino acids.
Within the coding sequence, there are two sumoylation sites and a single serine phosphorylation site.
There are three regions predicted to form alpha helices on the final protein.
Expression
C9orf152 is expressed in the bladder, intestine, mammary gland, and trachea and in smaller amounts in the lungs, liver, prostate, uterus, and brain. Within the brain, expression of C9orf152 is limited to the olfactory bulb. Gene expression was found to increase in the presence of stress, including disease and heat stress.
A wide variety of transcription factors interact with the promoter of C9orf152, most notably two olfactory related factors (specifically, a neuron-specific olfactory factor and an olfactory associated zinc finger protein) and a negative glucocorticoid response element.
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