HPE may refer to:
Cars Lancia Beta HPE, introduced 1975 Lancia Delta HPE, introduced 1995
Organizations Hennessey Performance Engineering, American hypercar manufacturer Hewlett Packard Enterprise, an American technology company spun-off from Hewlett-Packard in 2015 United Alignment of Nationalists (Greek: ), a Greek political alliance Êzîdxan Protection Force (Kurdish: )
Science and technology High-pressure electrolysis Holoprosencephaly, a cephalic disorder
Other uses High Point Enterprise, a US newspaper Hope railway station (Wales) (station code), in Flintshire, Wales