Lycée Descartes or Lycée français René-Descartes (LFRD) may refer to:
Schools in France: Lycée Descartes de Montigny le Bretonneux in Montigny le Bretonneux, Yvelines, Paris metropolitan area Lycée Descartes (Antony) in Antony, Hauts-de-Seine in Tours, Indre-et-Loire Lycée Descartes (Champs-sur-Marne) in Champs-sur-Marne, Seine-et-Marne, Paris metropolitan area Lycée Descartes (Cournon d'Auvergne) in Cournon d'Auvergne
French international schools outside France: Lycée Descartes (Rabat) in Rabat, Morocco Lycée français René-Descartes de Kinshasa - Democratic Republic of the Congo Lycée français René-Descartes de Phnom Penh - Cambodia
Bilingual schools outside France: Lycée Cheikh Bouamama, formerly Lycée Descartes, in Algiers, Algeria