Adverse effects by frequency for use of valproate semisodium.
Very common (>10% frequency)
Nausea Tremor
Common (1-10% frequency)
Liver injury Gastralgia Diarrhoea Extrapyramidal (movement) disorder Stupor Somnolence Convulsion Memory impairment Headache Nystagmus Confusional state Aggression Agitation Impaired attention Hyponatraemia Anaemia Thrombocytopaenia Hypersensitivity Transient and/or dose-related hair loss Dysmenorrhea Haemorrhage (bleeding) Weight gain
Uncommon (0.01-0.1% frequency)
Pancreatitis (sometimes lethal) Coma Lethargy SIADH Pancytopenia Leucopenia Rash Angioedema Amenorrhoea (absence of menstrual cycle) Vasculitis Peripheral oedema Reduced bone mineral density Osteopaenia Osteoporosis Pleural effusions Gingival enlargement
Rare (<0.01% frequency)
Reversible dementia Reversible cerebral atrophy Abnormal behaviour Psychomotor hyperactivity Learning disorder Hyperammonaemia Hypothyroidism Bone marrow failure Toxic epidermal necrolysis Stevens–Johnson syndrome Erythema multiforme DRESS syndrome Male infertility Polycystic ovaries Enuresis Reversible Fanconi syndrome Coagulation abnormalities Systemic lupus erythematosus Gynaecomastia
Notes
References