The following list contains adverse effects by incidence of trimethoprim/sulfamethoxazole.
Common (>1% frequency)
Fever Nausea Vomiting Diarrhea Weight loss Rash Muscle aches Joint pain Itch Aphthous stomatitis and sore mouth Hyperkalaemia (high blood potassium) Thrombocytopenia (low number of platelets in the blood)
Infrequently (0.1–1.0% frequency) Headache Jaundice Elevated liver transaminases Peripheral neuritis Drowsiness Constipation Photosensitivity (light sensitivity) Blood dyscrasias (e.g. neutropaenia)
Rare (<0.1% frequency)
Megaloblastic anaemia Methaemoglobinaemia Erythema multiforme Low blood sugar Hepatitis (liver swelling) Crystalluria (crystals in the urine) Urinary obstruction causing difficulty passing urine Lowered mental acuity Depression Tremor Aplastic anaemia Haemolytic anaemia Hyponatraemia Purpura Eosinophilia Agranulocytosis Serum sickness Anaphylaxis Allergic myocarditis Angioedema Drug fever Periarteritis nodosa Hepatic necrosis Pancreatitis Myelosuppression HaemolysisBreakdown of red blood cells. This side effect most often occurs in people with glucose-6-phosphate dehydrogenase deficiency Stevens–Johnson syndromeA potentially fatal skin reaction that causes the skin to slough off Drug reaction with eosinophilia and systemic symptoms Toxic epidermal necrolysisBasically a worse form of Stevens–Johnson syndrome AtaxiaIncoordination; most often after IV use in HIV patients Clostridioides difficile colitis Aseptic meningitisSwelling of the membranes surrounding the brain and spinal cord without any obvious infectious cause Pseudomembranous colitis Interstitial nephritis Fulminant hepatic necrosis Hypersensitivity of the respiratory tract Sore throat Pallor Arthralgia Severe Acute respiratory distress syndrome
Unknown frequency
Hallucinations Cough Glossitis Stomatitis Fatigue Insomnia Impaired kidney function Pulmonary infiltrationSign of hypersensitivity Shortness of breath
Notes
References