Demetrescu is a Romanian surname, derived from the root name Demetrius. Notable people with the surname include:

George Demetrescu Mirea, Romanian portrait painter, muralist, and art teacher Traian Demetrescu, Romanian poet, novelist, and literary critic Demetru Dem. Demetrescu-Buzău, better known as Urmuz

See also Dimitrescu Dumitrescu