Cristofori is an Italian surname. Notable people with the surname include:
Bartolomeo Cristofori (1655–1731), Italian musical instrument maker and inventor Carlo Cristofori (1813–1891), Italian cardinal Guido Cristofori (1880–?), an Italian gymnast Nino Cristofori (1930–2015), Italian politician Pierpaolo Cristofori (born 1956), Italian modern pentathlete