Pfenninger is a surname. Notable people with the surname include:
Fritz Pfenninger (1934–2001), Swiss cyclist Hans Pfenninger (1929–2009), Swiss cyclist Johann Konrad Pfenninger (1747–1792), Swiss theologian Louis Pfenninger (born 1944), Swiss racing cyclist Matthias Pfenninger (1739–1813), Swiss artist Otto Pfenninger (1855–1929), Swiss photographer