Cuno is both a given name and a surname derived from medieval diminutive forms of the German male name Conrad. Notable people with the name include:

Given name: Cuno Amiet (1868–1961), Swiss artist Cuno Hoffmeister (1892–1968), German astronomer Cuno of Öhningen (d. 997), duke of Swabia Cuno of Praeneste (died 1122), German cardinal Cuno Pümpin (born 1939), Swiss economist Cuno Tarfusser (born 1954), Italian judge Cuno von Uechtritz-Steinkirch (1856–1908), German sculptor Cuno (Disco Elysium), a video-game character

Surname: James Cuno (born 1951), American art historian and curator Kurt Cuno (1896–1961), German Wehrmacht general Wilhelm Cuno (1876–1933), German businessman, politician and chancellor of Germany (1922–1923)

See also 4183 Cuno, an asteroid Kuno (given name), often an alternative spelling of Cuno