DiMichele (or Di Michele in its original form) is a patronymic surname of Italian origin meaning "of Michele" (equivalent of Michael). Notable people with the surname include:

Adam DiMichele (born 1985), American former football player Alicia DiMichele (born 1973), former star of U.S. reality show Mob Wives David Di Michele (born 1976), Italian football player Frank DiMichele (born 1965), American former baseball player

See also