Huxford is a surname. Notable people with the surname include:
Cliff Huxford (1937–2018), English footballer and manager Merchant W. Huxford (1798–1877), American physician and politician Neville Huxford (1937–2006), New Zealand cricketer Richard Huxford (born 1969), English footballer Vanessa Huxford (born 1970), English rugby union player Walter S. Huxford (1892–1958), American physicist