Kefalogiannis () is a Greek surname with the female form being Kefalogianni (). Notable people with this surname include:
Aristidis Kefalogiannis (born 1960), Greek water polo player Ioannis Kefalogiannis (1933–2012), Greek politician and government minister Ioannis A. Kefalogiannis (born 1982), Greek politician Manolis Kefalogiannis (born 1959), Greek politician and government minister Olga Kefalogianni (born 1975), Greek politician and government minister