Huguenin is a surname. Notable people with the surname include:
Anne-Marie Huguenin (1875–1943), Canadian journalist Gustav Huguenin (1840–1920), Swiss internist and pathologist Marianne Huguenin (born 1950), Swiss politician Marcel Huguenin (1930–2020), Swiss cross-country skier René Huguenin (born 1944), Swiss ice hockey player Victor Huguenin (1802–1860), French sculptor