William Griffith McBride (25 May 1927 – 27 June 2018) was an Australian obstetrician. He published a letter on the teratogenicity of thalidomide in 1961,Papers of William McBride, ca. 1953-1996, National Library of Australia, accessed 26 July 20101960s Timeline – Australian Broadcasting CorporationPage 48 of The New Scientist, Page 48, Vol. 56 – published 5 October 1972Dove, Frederick. Thalidomide apology insulting, campaigners say BBC News 1 September 2012. Accessed 31 March 2017 following the findings of a midwife named Pat Sparrow. which resulted in the reduction of the number of drugs prescribed during pregnancy. Later in his life, McBride was involved in several trials with the pharma industry accusing him of medical malpractice and scientific fraud for falsifying data in a paper that claimed that the drug Debendox was also responsible for birth defects.
Early life McBride was born in Sydney, Australia.The most influential Australians – The Sydney Morning HeraldWilliam Griffith McBride biography – The University of Melbourne
Career Thalidomide case McBride published a letter in The Lancet, in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide,McCredie, Janet. The thalidomide story. Sydney Publishing (University of Sydney), 17 January 2016 after a midwife named Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. McBride was awarded a medal and prize money by , a prestigious French institute, in connection with his discovery, in 1971. Using the prize money, he established Foundation 41, a Sydney-based medical research foundation concerned with the causes of birth defects. Working with P H Huang, he proposed that thalidomide caused malformations by interacting with the DNA of the dividing embryonic cells. This finding stimulated their experimentation, which showed that thalidomide may inhibit cell division in rapidly dividing cells of malignant tumors. This work was published in the journal "Pharmacology and Toxicology" in 1999 and has been rated in the top ten of the most important Australian medical discoveries.
Debendox case McBride's involvement in the Debendox case is less illustrious. In 1981, he published a paper indicating that the drug Debendox (pyridoxine/doxylamine; marketed in the US as Bendectin) caused birth defects. His co-authors noted that the published paper contained manipulated data and protested.The Insider, Australian Story, 22 February 2001. Retrieved 26 July 2010 Multiple lawsuits were filed by patients. Eventually, the case was investigated and, as a result, McBride was struck off the Australian medical register in 1993 for deliberately falsifying data.Thalidomide hero found guilty of scientific fraud – The New Scientist, 27 February 1991 He was reinstated to the medical register in 1998.Medical Tribunal of New South Wales
Honours McBride was nominated Man of the Year for 1962,"Saviour of babies—The Man of the Year" – Article published on page 1 of The Daily Mirror (Sydney), Sydney, Friday, 28 December 1962. a Commander of the Order of the British Empire (1969 Birthday Honours),It's an Honour: CBE Father of the Year (1972) and an Officer of the Order of Australia (1977 Silver Jubilee and Queen's Birthday Honours).It's an Honour: AO"Book: The Trouble with Medicine"
Personal life
McBride had four children, one of whom is the soldier, lawyer, television presenter and whistleblower, David McBride.
Death McBride died on 27 June 2018, aged 91.
Oral history McBride was interviewed in 1972 by Hazel de Berg about his life and career. The recording can be found at the National Library of Australia.McBride, W.; de Berg, H. (interviewer). (1972). William McBride interviewed by Hazel de Berg in the Hazel de Berg collection [sound recording], National Library of Australia. Retrieved 5 May 2026.
See also List of scientific misconduct incidents
References
External links 1986 Portrait of William McBride – National Library of Australia