Proline-rich protein 23C is a protein that in humans is encoded by the proline-rich 23C (PRR23C) gene.
Gene
PRR23C Homo sapiens is located on the long arm of chromosome 3, (3q23) on the antisense strand. When pertaining to the mRNA of PRR23C Homo sapiens, it is 2,791 bp in length. PRR23C Homo sapiens has one exon covering the entire length of mRNA (1-2,791 bp). PRR23C Homo sapiens has a clone name of FLJ46210.
Expression
PRR23C Homo sapiens is expressed in the testis. Ottolini et al. (2014) discussed the PRR23 family to which they revealed that through RNA sequencing data, that PRR23A, PRR23B and PRR23C are testis-specific genes. Ottolini et al. (2014) believes that this family may be a crucial part for the male reproductive system given their RNA-seq data findings.
Protein Proline-rich protein 23C Homo sapiens is 262 amino acids long with a calculated molecular weight of 27,674 Da. Proline-rich protein 23C Homo sapiens has a domain of unknown function (DUF2476) that spans the majority of the protein (1-259 aa) which is a conserved domain. DUF2476 belongs to pfam10630 which is a part of superfamily c|11241. DUF2476 is a family of proteins that are rich in proline residues and have unknown function. Proline-rich protein 23C is the preferred name but other aliases include proline-rich protein 23A.
Protein composition
Proline is predicted to be the most abundant amino acid in proline-rich protein 23C Homo sapiens.Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification. In comparison to the prevalence of amino acids in other human proteins, it is predicted that proline-rich protein 23C Homo sapiens has a higher abundance of proline along with very low abundances of asparagine, threonine, and lysine.Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification. Orthologs for this protein are predicted to also have a high abundance of proline.Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
Isoelectric point
The basal isoelectric point for PRR23C Homo sapiens was 4.48 (pH) according to phoshosite.org.
Sub-cellular localization
Proline-rich protein 23C is predicted to localize to the nucleus for the human protein and its orthologs.PSORTII http://www.genscript.com/psort/psort2.html There are predicted nuclear localization signals seen in both the human proline-rich protein 23C and its orthologs.PSORTII http://www.genscript.com/psort/psort2.html
Homology Orthologs
PRR23C Homo sapiens is strictly conserved in mammals. The table below lists mammalian orthologs for PRR23C Homo sapiens . Genus & Species Common name Accession number Seq. Length Seq. Identity Seq. Similarity Homo sapiens Human NP_001128129.1 262 aa 100% 100% Pan troglodytes Chimpanzee XP_003310067.1 263 aa 98.50% 98% Gorilla gorilla gorilla Western lowland gorilla XP_004037787.1 263 aa 96.60% 98% Pongo pygmaeus Bornean orangutan XP_002814147.1 263 aa 94.70% 95% Nomascus leucogenys Northern white-cheeked gibbon XP_003265349.1 262 aa 94.70% 95% Chlorocebus sabaeus Green monkey XP_008007123.1 263 aa 92% 94% Rhinopithecus roxellana Golden snub-nosed monkey XP_010365056.1 263 aa 91.60% 93% Papio anubis Olive baboon XP_003895087.1 263 aa 94.70% 93% Callithrix jacchus Common marmoset XP_002759594.1 248 aa 72.90% 77% Otolemur garnettii Northern greater galago XP_003789481.1 267 aa 66.50% 71% Ceratotherium simum simum White rhinoceros XP_004419371.1 263 aa 63.70% 75% Pteropus alecto Black flying fox XP_006907344.1 268 aa 50.90% 68% Myotis lucifugus Little brown bat XP_006083994.1 257 aa 61.20% 64% Bubalus bubalis Water buffalo XP_006070045.1 258 aa 55.40% 62% Bison bison bison American bison XP_010856601.1 258 aa 51.90% 61% Bos mutus Yak XP_005909007.1 258 aa 51.50% 61% Lipotes vexillifer Baiji XP_007458979.1 260 aa 51.50% 64% Tursiops truncatus Common bottlenose dolphin XP_004330081.1 261 aa 54.50% 61% Balaenoptera acutorostrata scammoni Minke whale XP_007170446.1 255 aa 53.60% 61% Physeter catodon Sperm whale XP_007117538.1 260 aa 53.80% 64% Peromyscus maniculatus bairdii Prairie deer mouse XP_006975251.1 266 aa 50.90% 60%
Paralogs
There were two paralogs found for PRR23C Homo sapiens: PRR23B and PRR23A. Both have similar sequence identities with PRR23B having 86% identity and PRR23A having 85% identity.
References