GPE may refer to:
Computing Geopolitical entity, in named-entity recognition GPE Palmtop Environment, a user interface Google Play edition, a mobile device series Google Plugin for Eclipse, in software development
Education Global Partnership for Education, a World Bank programme Global Peace Exchange, at Florida State University, United States General physical education; see adapted physical education
Science Gravitational potential energy External globus pallidus (GPe) Gross–Pitaevskii equation, in quantum physics GYPE, a protein
Transport GP Express Airlines, an American airline Grand Paris Express, an extension of the Paris metro network
Other uses European Grand Prix for Choral Singing General Precision Equipment, a former American manufacturing company Ghanaian Pidgin English Global political economy Guadeloupe national football team