Mesilla may refer to:
Places Mesilla, New Mexico, a town in southern New Mexico, United States Mesilla Park, New Mexico, a neighborhood in Las Cruces, New Mexico Mesilla Plaza, a plaza in Mesilla, New Mexico Mesilla Valley, a valley in New Mexico and Texas Mesilla Valley AVA, a wine growing area in New Mexico and Texas Mesilla Valley Bosque State Park, a state park in New Mexico Mesilla Valley Mall, a mall in Las Cruces, New Mexico Mesilla Valley Shale, a geologic formation in New Mexico La Mesilla, a village in Guatemala La Mesilla, New Mexico, a census-designated place in northern New Mexico
Other Mesilla (spider), a spider genus Mesilla Diversion Dam, a dam in Texas First Battle of Mesilla, an 1861 battle in Mesilla Second Battle of Mesilla, an 1862 battle in Mesilla Treaty of Mesilla, the Gadsden Purchase agreement between Mexico and United States Basilica of San Albino, formerly known as San Albino Church of Mesilla Halcones FC, a football club in Huehuetenango, Guatemala, formerly known as Peñarol La Mesilla
See also Battle of Mesilla (disambiguation)