The Computational and Structural Biotechnology Journal is a peer-reviewed open-access scientific journal, published as part of the Science Partner Journal (SPJ) program of the American Association for the Advancement of Science. The journal was published by Elsevier on behalf of the Research Networks until 2025, covering all aspects of computational and structural biology. It was established in 2012, and the editor-in-chief is Gianni Panagiotou (Hans Knöll Institute).

Sections The journal is organized into subject-specific sections: General Smart Hospital Nanoscience & Advanced Materials Quantum Biology & Biophotonics

Abstracting and indexing The journal is abstracted and indexed in Chemical Abstracts Service, Global Health, Proquest databases, Science Citation Index Expanded, CAB International, MEDLINE/PubMed, Inspec, and Scopus.

According to the Journal Citation Reports, the journal has a 2025 impact factor of 4.8.

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