Manasota may refer to:
Places Manasota, Florida, a community in Sarasota County, Florida Manasota Key, Florida, a census-designated place in Charlotte County, Florida Manasota Scrub Preserve, an area of protected land in Sarasota County, Florida
Other uses Manasota culture, an archaeological culture of southwestern Florida Manasota Key Offshore, an underwater archaeological site in the Gulf of Mexico