Mazzacurati is a family name of Italian origin literally translating 'priest-killer'. It may refer to:
Anna Maria Mazzacurati (born 1944), Italian javelin thrower Carlo Mazzacurati (1956–2014), Italian film director and screenwriter Italo Mazzacurati (1932–2013), Italian racing cyclist Marino Mazzacurati (1907–1969), Italian painter and sculptor Mario Mazzacurati (1903–1985), Italian engineer and auto racer driver Rosy Mazzacurati (1935–2020), Italian film and stage actress