Santuzza may refer to:
A character in Pietro Mascagni's 1890 opera Cavalleria rusticana A local nickname for Saint Rosalia (1130–1166), patron saint of Palermo, Sicily, Italy Santuzza, Missouri, an unincorporated community in Lewis County, Missouri, U.S. Santuzza (moth), a genus of the family Lecithoceridae
See also Santina Santucci In the Garden of Papa Santuzzu, a 1999 novel by Tony Ardizzone