Manuel Velasco may refer to:
Manuel Velasco Coello (b. 1980), Mexican politician, Governor of Chiapas from 2012 to 2018 Manuel Velasco Suárez (1914–2001), Mexican neurologist and Governor of Chiapas from 1970 to 1976 Manuel de Velasco y Tejada, Spanish admiral during the Battle of Vigo Bay (1702) Victor Manuel Velasco Herrera, Mexican theoretical physicist