Santucci is a surname. Notable people with the surname include:
Angelo Santucci (born 1952), Canadian Football League player Antonio Santucci (died 1613), Italian astronomer, cosmographer, and scientific instrument maker Antonio Santucci (bishop) (1928–2018), Italian Roman Catholic bishop Barbara Santucci (born 1947), American artist, poet and author Clara Santucci (born 1987), American long-distance runner Dan Santucci (born 1983), American football player Facundo Santucci (born 1987), Argentine male volleyball player Graziano Santucci (died 1517), Italian Roman Catholic Bishop of Alatri John J. Santucci (1931–2016), New York politician, D.A. of Queens County Lavinia Santucci (born 1985), Italian female basketball player Michele Santucci (born 1989), Italian Olympic swimmer Pat Santucci (1924–1992), Canadian football player Paul Santucci, American politician Roberto Santucci (born 1967), Brazilian filmmaker Serge Santucci (born 1944), French sculptor and medallist Tyler Santucci (born 1988), American football coach Vincenzo Santucci (1796–1861), Italian Roman Catholic cardinal
See also Mariam Habach Santucci (born 1996), Miss Venezuela 2015 Palazzo Santucci, Renaissance palace