Frain is a surname. Notable people with the surname include:
David Frain (born 1962), an English footballer Irène Frain (born 1950), French writer James Frain (born 1968), an English actor John Frain (born 1968), an English footballer, brother of Peter Peter Frain, an English footballer, brother of John Rose Frain, a British artist Todd Frain (born 1962), an American football player Travis D. Frain (born 1998), English political advocate
See also Darren DeFrain (born 1967), an American author