Guise is a surname possibly derived from the Guise baronets of England or from Guise, a commune in France. Notable people with the name include:
Anthony Guise (born 1985), French footballer Berkeley Guise, 2nd Baronet (1775–1834), British landowner and Member of Parliament Sir Christopher Guise, 1st Baronet (died 1670), English politician Dianne Guise (born 1952), Australian politician John Guise (disambiguation) Wit Lefty Guise (1908–1968), American Major League Baseball pitcher Martin Guise (1780–1828), British-Peruvian admiral Tom Guise (1857–1930), American actor William Guise (disambiguation) Wyndham Guise (active 1913–1929), British actor
See also Guise (disambiguation) General Guise (disambiguation) Mademoiselle de Guise (disambiguation) Michel DeGuise (born 1951), Canadian ice hockey player