Big Up or Big Ups may refer to:
Big Up (group), a Black gay men's group that merged with GMFA Big Up (album), a 1987 album by Aswad "Big Up" (song), a song by Shaggy "Big Up", a 2005 song by Avalon Big Ups (band), American musical band Big UP Productions, American film production company The Big Up Festival, a festival of music, art and culture in Ghent, New York