The Wynne Post Office is located at 402 East Merriman Street in Wynne, Arkansas. It is a single-story brick structure, with a built-up parapet obscuring a flat roof. A recent addition extends to the rear. The building was built in 1936 at a cost to the federal government of $65,000. It is most notable for the mural that adorns its main lobby, titled Cotton Pickers, which was created by Ethel Magafan with funding from the United States Treasury Department's Section of Art, a Depression-era jobs program for artists.
The building was listed on the National Register of Historic Places in 1998.
See also National Register of Historic Places listings in Cross County, Arkansas List of United States post offices List of United States post office murals
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