Manolescu is a Romanian surname that may refer to:

Ciprian Manolescu (1978–), mathematician Nicolae Manolescu (1939–2024), literary critic Ion Manolescu-Strunga (1889–1951), liberal politician Mihail Manoilescu (1891–1950), fascist politician

See also Manole (name) Manolescu (film) Manolescu's Memoirs