Mushegh Mamikonian or Mušeł Mamikonian () can refer to one of the following members of the noble Armenian Mamikonian family:
Mushegh I Mamikonian, sparapet and regent of Arsacid Armenia in the 370s Mushegh II Mamikonian, marzban of Persian Armenia in 591 Mushegh III Mamikonian, killed fighting alongside the Persians at the Battle of Qadisiyya in 636 Mushegh IV Mamikonian, sparapet of Armenia in the 650s Mushegh V Mamikonian, sparapet of Armenia in 706–709 Mushegh VI Mamikonian, ishkhan of Armenia in 748–753, killed at the Battle of Bagrevand in 775