Centerville Historic District is a national historic district in Winston-Salem, Forsyth County, North Carolina. The district encompasses 91 contributing buildings and 1 contributing structure in Winston-Salem. It includes a mix of residential, commercial, and light industrial buildings built between about 1900 and 1950. Residential buildings are in a mix of architectural styles including Queen Anne, Bungalow / American Craftsman, and Minimal Traditional.

It was listed on the National Register of Historic Places in 2008.

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