Holle is a surname. Notable people with the surname include:
Alexander Holle (1898–1978), German soldier Eric Holle (born 1960), American football player Fred Holle (born 1931), American artist Gary Holle (born 1954), American baseball player Karel Holle (1829–1896), Dutch colonial administrator Lienhart Holle (fl. 1478–92), printer from Ulm, Germany Mabel Holle (1920–2011), American baseball player Ryan Holle (born 1982), American murderer