Pee Dee is a region of South Carolina.

Pee Dee or Peedee may also refer to the Pee Dee River or the following:

People Pedee people, also spelled Pee Dee and Peedee, a historic Native American people, once concentrated in South Carolina Pee Dee Lumbee, modern communities of Lumbee descent in Pee Dee region of South Carolina

Places Little Pee Dee River, tributary of the Pee Dee River Pee Dee, Anson County, North Carolina, United States, a populated place Pee Dee, Montgomery County, North Carolina, an unincorporated community Pee Dee Avenue Historic District, national historic district located at Albemarle, Stanly County, North Carolina. Pee Dee Creek, many streams Pee Dee National Wildlife Refuge, in Anson and Richmond Counties, North Carolina Pee Dee River, in North and South Carolina Peedee Formation, a geologic formation in North and South Carolina

Sports Pee Dee Cyclones, a minor league ice hockey team based in Winston-Salem, North Carolina Pee Dee Pride, a professional minor-league hockey team that was based in Florence, SC

Transportation CSS Peedee, also known as CSS Pee Dee, a Confederate gunboat. Pee Dee Bridge Company, South Carolina railroad company Pee Dee River Railway, South Carolina Wilmington—Pee Dee Line, railroad line running from Wilmington, North Carolina west to Pee Dee, South Carolina

Other Nickname for the Cleveland Plain Dealer, the major daily newspaper of Cleveland, Ohio, United States PeeDee the Pirate, mascot of the East Carolina Pirates Peedee Fryman, a fictional character on Steven Universe Pee Dee Light Artillery, a distinguished Confederate artillery battery during the American Civil War Pee Dee Area Council, Boy Scouts organization in northeastern South Carolina

See also PD (disambiguation) Pee Dee, North Carolina