Jentsch is a German surname. Notable people with the surname include:
Adolph Jentsch (1888–1977), German-born Namibian artist Daniela Jentsch (born 1982), German curler Elaine Jentsch (born 1994), German politician Ernst Jentsch (1867–1919), German psychiatrist J. David Jentsch (born 1972), American neurobiologist Julia Jentsch (born 1978), German actress Martina Jentsch, (born 1968), German gymnast Roland Jentsch, German curler Stefan Jentsch (1955–2016), German biologist