The 2000–01 Israel State Cup (, Gvia HaMedina) was the 62nd season of Israel's nationwide football cup competition and the 47th after the Israeli Declaration of Independence.
The competition was won by Maccabi Tel Aviv who had beaten Maccabi Petah Tikva 3–0 in the final.
By winning, Maccabi Tel Aviv qualified to the 2001–02 UEFA Cup, entering in the qualifying round.
Results Seventh Round Home teamScoreAway team
Byes: Hapoel Majd al-Krum, Ironi Ofakim, Maccabi Isfiya, Maccabi Tur'an.
Intermediate Round Home teamScoreAway team
Eighth Round Home teamScoreAway team
Round of 16 Home teamScoreAway team
Quarter-finals Home teamScoreAway team
Semi-finals Home teamScoreAway team
Final
References 100 Years of Football 1906–2006, Elisha Shohat (Israel), 2006, pp. 313–14 Israel Cups 2000/01 RSSSF