Shires is a surname of British origin. Notable people with the surname include:
Abe Shires (1917–1993), American football player Alan Shires (born 1948), English footballer Amanda Shires (born 1982), American singer-songwriter and violinist Art Shires (1906–1967), American baseball player Ben Shires (born 1985), British television presenter Corbin Shires (born 1997), English footballer Dana Shires (born 1932), American physician, co-inventor of Gatorade Jim Shires (born 1945), Canadian ice hockey player Tom Shires (1925–2007), American trauma surgeon