Defoe may refer to:
People Defoe (surname), most notably English author Daniel Defoe
Places Defoe, Webster County, West Virginia, an unincorporated community
Other uses Defoe (comics), a zombie story Defoe Shipbuilding Company, a former shipyard in Bay City, Michigan Operation Defoe, a Second World War reconnaissance by the British Special Air Service Defoe (horse) (2014–2020), Thoroughbred racehorse
See also Dafoe (disambiguation) Foe (disambiguation)