The 1980–81 Israel State Cup (, Gvia HaMedina) was the 42nd season of Israel's nationwide football cup competition and the 27th after the Israeli Declaration of Independence.

The competition was won by Bnei Yehuda who have beaten Hapoel Tel Aviv 4–3 in penalty shoot-out, after 2–2 in the final.

Format Changes Starting with this edition, if a match is drawn, a replay is to be played, drawn replays are to be settled with extra time and penalty shootouts. This does not include the final and the semi-final, which are still to be settled without replays.

Results Fifth Round Home teamScoreAway team

Sixth Round Home teamScoreAway team

Seventh Round Home teamScoreAway team

Round of 16 Home teamScoreAway team

Quarter-finals Home teamScoreAway team

Semi-finals Home teamScoreAway team

Final

References 100 Years of Football 1906–2006, Elisha Shohat (Israel), 2006, p. 250 5 upsets in the Football State Cup Davar, 25.1.1981, Historical Jewish Press Kiryat Gat - Lod 4:2; Sderot - Beitar Tel Aviv 0:0 Davar, 22.2.1981, Historical Jewish Press Upset in the State Cup: Maccabi Be'er Sheva (Liga Bet) eliminated Kiryat Shmona Davar, 4.3.1981, Historical Jewish Press Bnei Hatzor from Liga Bet upset Givat Olga Davar, 5.3.1981, Historical Jewish Press Cup (Pages 2-5) Hadshot HaSport, 15.3.1981, archive.football.co.il Cup (Page 7) Hadshot HaSport, 18.3.1981, archive.football.co.il