GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin lymphoma, including those patients who relapse after stem cell transplantation.Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804

The GVD regimen consists of three drugs, from which its name is derived: Gemcitabine; Vinorelbine; and Doxil, a pegylated liposomal formulation of doxorubicin.

Dosing

Drug Dose in transplant-naive patients Dose in post-transplant patients Mode Days Gemcitabine 1000 mg/m2 800 mg/m2 IV infusion Days 1, 8 Vinorelbine 20 mg/m2 15 mg/m2 IV bolus Days 1, 8 Doxil 15 mg/m2 10 mg/m2 IV infusion Days 1, 8

Repeated every 21 days (3 weeks).

References