Zilkha is a surname. Notable people with the surname include:
Donald Zilkha (born 1951), American financier, son of Ezra Ezra Zilkha (1925–2019), American financier Khedouri Zilkha (1884–1956), Iraqi banker Maurice Zilkha (1918–1964), Iraqi banker Michael Zilkha (born 1954), British-born entrepreneur, son of Selim Selim Zilkha (1927–2022), Iraqi businessman