Zamudio is a Spanish surname. Notable people with the surname include:
Adela Zamudio (1854–1928), Bolivian poet and feminist Alejandro Zamudio (born 1998) Mexican footballer Daniel Zamudio (1987–2012), Chilean man murdered in 2012 Delia Zamudio (1943–2024), Peruvian trade unionist Gustavo Zamudio (born 1985), Chilean footballer Héctor Fix-Zamudio (born 1942), Mexican jurist Ignacio Zamudio (born 1971), Mexican race walker Jesse Zamudio (born 1999), Mexican footballer José Mario Carrillo Zamudio (born 1956), Mexican football coach Kelly Zamudio, US American biologist Luis Zamudio (born 1998), US American soccer (football) player María Zamudio Guzmán (born 1961), Mexican politician Raúl Zamudio, US American art critic Ysaias Zamudio (born 1969), Mexican boxer Yulissa Zamudio (born 1976), Peruvian volleyball player